Research Summary Archives

  This article at a glance The conversion of alpha-linolenic acid (ALA) to longer chain and more desaturated omega-3 polyunsaturated fatty acids (omega-3 LCPUFA), in particular to DHA, is  limited in humans consuming a Westernized diet.A recent intervention study that evaluated the effect o...

  This article at a glance This is the first study that documents the status of omega-3 long-chain polyunsaturated fatty acids (omega-3 LCPUFA) in players of American Football, a sport where players receive many sub-concussive impacts over a playing season.Omega-3 LCPUFA levels decreased signifi...

This article at a glance This study identifies the omega-3 polyunsaturated fatty acid hexadecatetraenoic acid (16:4 n-3) as a ligand of GPR120, a receptor studied for its role in regulating inflammation, energy metabolism and satiety. 16:4 n-3, previously identified as a fatty acid released ...

This article at a glance A thin, pliable, biodegradable multi-layered material incorporating the DHA-derived lipid mediator resolvin D1 (RvD1) was developed. The thin-film device allowed sustained diffusion of RvD1 from the surface with the lowest copolymer density, permitting one-sided release...

Jean-Marie Galano, Camille Oger, Valérie Bultel-Poncé, Guillaume Reversat, Alexandre Guy, Joseph Vercauteren, Claire Vigor, Thierry Durand. Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université de Montpellier, ENSCM, Montpellier, France.   Thierry Durand Institut des Bi...

This article at a glance This study reports a 22-bp nucleotide insertion-deletion (indel) genetic polymorphism that may be causally related to the control of gene expression of the fatty acid desaturases, enzymes that control the biosynthesis of long-chain polyunsaturated fatty acids (LCPUFA) fro...

Professor Anne Marie Minihane Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia (UEA), Norwich, UK Website: https://www.uea.ac.uk/medicine/people/profile/a-minihane   Setting the Scene A large body of human prospective epidemiology, as well as...

The 10th Congress of the International Society for the Study of Fatty Acids and Lipids (ISSFAL) convened May 26-30, in Vancouver, Canada, overlooking the North Shore Mountains, Coal Harbor and Stanley Park. Three days packed with meetings, breakfast workshops, plenary and poster sessions, exhibits a...

Descriptions of Alzheimer’s disease, a progressive degenerative condition that robs its victims of their memory, cognitive function, language and ability to take care of themselves, centers on the accumulation of abnormal proteins amyloid-beta and tau. Amyloid-beta proteins form plaques outside the ...

Suicide is a global problem that is more prevalent among adolescents, the elderly, war veterans and active-duty military personnel. The latter are of particular concern regarding the Iraq and Afghanistan wars, among whom suicide is the second leading cause of death (13.1%) compared with the ninth ra...

Traumatic brain injury results in 53,000 deaths in the U.S. every year (Figure), with nearly twice that number suffering permanent disability, including diminished cognitive ability. Treatments with long-term benefits are few and of limited effectiveness.  Progesterone may have neurological benefits...

Trevor A Mori, Ph.D., Professor, School of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia. Many of the cardiovascular benefits ascribed to omega-3 (n-3) fatty acids were initially attributed to eicosapentaenoic acid (EPA) rather than docosahe...